Painkillers

Mechanism of Action Vitamin B1 + Vitamin B6 + Vitamin B12 This combination of water-soluble B vitamins: thiamine (vitamin B1), pyridoxine (vitamin B6), and cyanocobalamin (vitamin B12) is administered orally. It directly influences the nociceptive transmission pathways in the spinal cord or thalamus. Vitamins are essential nutrients involved in numerous processes of human metabolism. Therapeutic Indications Vitamin B1 + Vitamin B6 + Vitamin B12 It is indicated for: Prevention and treatment of deficiency states of vitamins B1, B6, and B12 due to increased needs, reduced consumption, or reduced absorption, which could manifest as back pain, convalescence, or inadequate diet.

TYLENOL® contains an active ingredient, acetaminophen, a fever-reducing analgesic that acts directly after 30 minutes, increasing your body's overall tolerance so you feel less pain and lowering your fever, helping your body control excess body heat.

Indicated for acute cases and exacerbations in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis; relief of pain and inflammation from acute gouty arthritis, acute and subacute bursitis, tendonitis, and synovitis.

Capsule treatment that relieves the most common symptoms of the flu. FLU RELIEF that RELIEVES the symptoms of the flu (cough, fever, body aches, nasal congestion, runny nose) as well as the annoying symptoms of a cough with its main active ingredient, dextromethorphan.

Acemetacin is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in rheumatic diseases and other musculoskeletal disorders. If discomfort persists, consult your doctor.

Aspirin helps increase blood flow to the legs. It can be used to treat a heart attack and prevent blood clots when you have an abnormal heart rhythm. It works by reducing pain and fever. This medication is indicated for the symptomatic relief of mild to moderate occasional pain, such as headaches, toothaches, menstrual pain, muscle pain (contractures), or back pain (lumbago).

Aspirin, the active ingredient in this medication, works by reducing pain and fever. This medication is indicated for the symptomatic relief of mild to moderate occasional pain, such as headaches, toothaches, menstrual pain, muscle pain (contractures), or back pain (lumbago). If discomfort persists, consult your doctor.

Over-the-counter effervescent medication for rapid pain and fever relief If discomfort persists, consult your doctor.

Over-the-counter tablet medication for rapid pain and fever relief If discomfort persists, consult your doctor.

Aspirin, the active ingredient in this medicine, works by reducing pain and fever. This medicine is indicated for the symptomatic relief of mild to moderate occasional pain, such as headaches, toothaches, menstrual pain, muscle pain (contractures), or back pain (lumbago).

A medication composed of ampicillin, metamizole, guaifenesin, chlorpheniramine, and lidocaine indicated for combating bacterial infections of the upper respiratory tract. It relieves symptoms such as malaise, pain, fever, nasal congestion, and sneezing.

AMPIGRIN-PFC-30mlGTS-CHLORPHENAMINE-PARACETAMOL-AMANTADINE It is indicated for the treatment of influenza A virus, as it has antiviral, analgesic, antipyretic, decongestant, and antihistamine properties.

Antacsal is an analgesic and antipyretic medication used to relieve mild to moderate pain and fever. Acetylsalicylic acid, the active ingredient in Antacsal, works by reducing inflammation, pain, and fever. Antacsal can be used to relieve: Headaches, Toothaches, Menstrual pain, Muscle pain, and Back pain.

Analgesic-antiemetic, aids in vascular headaches; "migraine." Lysine Acetylsalicylate: Lysine acetylsalicylate in solution is rapidly absorbed, primarily in the upper small intestine; once absorbed, it is hydrolyzed to aspirin, which is rapidly converted into salicylic acid. Acetylsalicylic Acid: Absorption is generally rapid and complete in the stomach and upper small intestine after oral administration. It is distributed into all body tissues and cellular fluids; the volumes of distribution of usual doses of aspirin and salicylate in normal subjects average 170 ml/kg of body weight. Eighty to 90% of salicylate is bound to plasma proteins, particularly albumin; this fraction decreases as plasma concentrations increase. Salicylate compounds other than salicylamide are extensively hydrolyzed in the gastrointestinal tract, liver, and blood to salicylate, which is then metabolized primarily in the liver. Aspirin has a half-life of 15 to 20 minutes (for the intact molecule); as a salicylate, the half-life is 2 to 3 hours with a single dose; with repeated dosing using antirheumatic drugs, it may vary from 5 to 18 hours. Peak plasma concentrations (Cmax 25 to 50 mcg/mL) are generally reached within 1 to 2 hours with a single dose. Elimination is renal, primarily as free salicylic acid and conjugated metabolites. Salicylates are excreted in the urine as free salicylic acid (10%), salicyluric acid (75%), salicylic phenolic glucuronides (10%), and acyl glucuronides (5%). However, the excretion of free salicylate is highly variable and depends on the dose and urine pH. Metoclopramide: Metoclopramide is rapidly absorbed, both through the digestive and parenteral routes. It reaches its maximum plasma concentration between 45 and 90 minutes when administered orally; peak concentrations increase linearly with dose. The oral bioavailability of metoclopramide is 80%; interindividual variability is linked to first-pass hepatic metabolism. Metoclopramide is rapidly and widely distributed into tissues, with an apparent volume of distribution of approximately 3.5 L/kg, crossing the blood-brain barrier. It is 30% bound to plasma proteins. The elimination half-life is 5-6 hours in individuals with normal renal function; however, in the presence of renal damage, it may be prolonged, resulting in elevated plasma concentrations. Therefore, dose adjustment is recommended in these cases. 85% of orally administered metoclopramide is excreted via the kidneys, appearing in the urine within 72 hours. 20-30% is excreted in free form and 50% in conjugated form (sulfoconjugates). 5% of the dose is excreted in feces through the biliary tract.

ARCOXIA belongs to a class of nonsteroidal anti-inflammatory drugs (NSAIDs) known as cyclooxygenase-2 (COX-2) inhibitors, which work by reducing pain and inflammation. ARCOXIA is indicated to relieve the symptoms of osteoarthritis, rheumatoid arthritis, and gout.

ARCOXIA belongs to a class of nonsteroidal anti-inflammatory drugs (NSAIDs) known as cyclooxygenase-2 (COX-2) inhibitors, which work by reducing pain and inflammation. ARCOXIA is indicated to relieve the symptoms of osteoarthritis, rheumatoid arthritis, and gout.